My ambitions include development of spectroscopic techniques, particularly Raman, for use in applications including biology and chemistry, and advance techniques combining imaging and spectroscopy. The biological uses include the spectroscopic diagnosis, probing of molecular information of cells, their structure and contents. I am also interested in interface chemistry, surfactants and other molecules adsorbing to surfaces; combining different techniques to observe these species, both kinetically and at equilibrium.
Working at Gloucestershire Hospitals NHS Foundation Trust, with Dr Catherine Kendall, Prof Nick Stone at the University of Exeter, and Dr John Day at the University of Bristol, I have focused on developing Raman probes for in vivo diagnosis of cancers including those of oesophageal, thyroid, breast and lymphomas. I am involved with an OCT project to advance the diagnosis of glaucoma. I have a background in studying kinetics and using multivariate analysis techniques. I have always been fascinated with optics, lasers and spectroscopy and computing and find fascination using them as tools to expand our scientific knowledge.
I am part of an EU Horizon 2020 project, GALAHAD, looking to develop a state-of-the-art OCT (optical coherence tomography) device for the diagnosis for glaucoma (an eye disease).
I am part of a team working to develop an endoscopic probe to diagnose oesophageal cancer using Raman spectroscopy.
I continued development and testing of a subcutaneous Raman needle probe. I redesigned and built the probes to be more compact and ergonomic, with improved ambient light rejection. I improved the design to develop a prototype which could be used by clinicians. I visited clinics and surgery to witness how the device would be used. This involved the construction of optical fibre assemblies and extensive use of CAD (Autodesk Inventor, SOLIDWORKS and CREO), as well as 3D printing.
During my PhD in Professor Bain's group, funded by Unilever and The EPSRC through CASE, I designed and built a total-internal reflection Raman spectrometer. Using the spectrometer, I investigated the adsorption of surfactants to the liquid-solid interface at the Department of Chemistry, Durham University. The research focused on the kinetics of adsorption, obtaining isotherms and forming mono/bi-layers of various ionic and nonionic surfactants on surfaces including silica, polyester and zeolite. A major part of the project was the design and construction of the spectrometer, during which I developed the skills needed to design and manipulate optics to obtain good signal to noise levels.
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Additionally in Professor Bain's group, I investigated the processes by which water and surfactant solutions penetrate macroscopic, horizontal, hydrophilic glass capillaries. I also investigated capillaries made hydrophobic by silanisation. To record the penetration rate, the meniscus, illuminated by collimated laser light, was tracked using a high-speed camera. Theoretical models (The Lucas-Washburn model, a "Young" model and an overflowing-cylinder model) were compared with our experimental data and the models were shown to be unable to account for the observed penetration rates. Instead, we considered the additional dissipation in the wedge of liquid near the three-phase contact line.
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University of Durham, Chemistry PhD Dunelm
University of Durham, Chemistry MSc Dunelm
University of Durham, Chemistry BSc (Hons.) Dunelm 2:II
Glyn Technology School, Ewell, SurreyChemistry, Human Biology, Physics, Mathematics (Pure)
Designed, constructed and commissioned a Total-internal Reflection Raman Spectrometer
Experience using: Lasers, IR/UV-vis spectroscopy, AFM, NMR, SEM, ellipsometry, neutron reflectometry, mass spectrometry, physical vapour deposition, plasma cleaning, Rutherford back scattering, optical imaging, microscopy, ellipsometry, Langmuir troughs, drop shape analysis
Experience coding in MATLAB, Python, LabVIEW, C, PHP, VBScript on Windows and Linux to build particle tracking, edge finding, data acquisition, factor analysis and imaging processing programs
Experience designing and constructing electrical circuits, computer I/O interfaces
2019-2022 NIHR - DOLPHIN-VIVO (Diagnosis Of LymPHoma IN VIVO) £971,826 (Co-I)
2018-2019 Cheltenham and Gloucester Hospitals Charity FOCUS - RAFTER (RAman For Thyroid cancER) £11079 (PI)
2017-2018 University of Exeter Proof of Concept Funding - Raman needle probe for in vivo identification of breast cancer £51,855 (Co-I)
L. M. Fullwood, I. E. Iping Petterson, A. P. Dudgeon, G. R. Lloyd, C. Kendall, C. Hall, J. C. C. Day and N. Stone, “Evaluation of a multi-fibre needle Raman probe for tissue analysis”, Proc. SPIE, 9704, (2016), 97040G. (Link)
A. P. Dudgeon, "Surfactant adsorption by total internal reflection Raman spectroscopy", IRDG 12th Martin & Willis Prize Meeting, University of Strathclyde, Glasgow, (2013)
D. A. Woods, A. P. Dudgeon and C. D. Bain, "Total internal reflection Raman spectroscopy of organic films at solid-water interfaces" 245th National Meeting of the American-Chemical-Society , 245, (2013)
A. P. Dudgeon, J. Harris, P. Starck, and C. D. Bain, "Surfactant adsorption by total internal reflection Raman spectroscopy", Faraday Discussion 160: Ion Specific Hofmeister Effects , Queens College, Oxford, (2012)
A. P. Dudgeon, J. Harris, P. Starck, and C. D. Bain, "Surfactant adsorption by total internal reflection Raman spectroscopy", ICORS 23rd International Conference on Raman Spectroscopy, IISC, Bangalore, India (2012)
A. P. Dudgeon, "Penetration of Surfactant Solutions into Capillaries", MSc Thesis, University of Durham, (2011) (Link)
2019 | World Spectroscopy Congress 2019 | Stockholm, Sweeden
2018 | West Midlands Surgical Society 2018 | Queen Elizabeth Hospital Birmingham, UK
2018 | SPEC2018 | University of Strathclide, UK
2017 | CLIRCON17 | University of Manchester, UK
2016 | SPEC2016 | Montréal, Canada
2014 | IRDG 207 "From cancer diagnosis to drug release: vibrational spectroscopy in biomedical science" | AstraZeneca, Macclesfield, UK
2010 | IRDG 192, | Manchester University, UK
2009 | SCI McBain Medal Award Lecture | SCI Headquarters, London, UK
2011-2013 | Supervision of our group's fourth year master's students
2011-2014 | Ten hours per year Hückel Theory workshop demonstrating and marking of scripts
2010-2014 | Up to six hours per week undergraduate physical lab demonstrating to years 1 and 2
2011-2014 | College Mentor at Van Mildert College, Durham University
I have also volunteered with Durham's outreach program helping at: Big Bang North East (2011-2012), Durham City's Celebrate Science Festival (2010-2011), and ran the chemistry program for Durham Schools' Science Festival (2011).
Biophotonics Research Unit | Gloucestershire Hospitals NHS FT, Gloucester, GL1 3NN
Working under Dr Catherine Kendall and Prof Hugh Barr, I worked on the project to take the Raman oesophageal device for the first in-human trials, and worked on an EU project to advance glaucoma diagnosis.
Department of Physics | University of Exeter, Exeter, EX4 4QL
Working under Professor Nick Stone in the Biomedical Spectroscopy Team, part of the Biophysics Group. I worked on the design and manufacture of, and ex vivo lymph node study using the Raman needle probe. I then developed the device to work on breast cancer. I also worked on the regulatory approval for an in vivo study using a Raman oesophageal probe.
Chemistry Department | University of Durham, Durham, DH1 3LE
Responsible for ensuring supplies remain stocked, health and safety procedures were adhered to, cleaning rotas, and hazardous waste disposed of correctly. Required an overall understanding of all equipment in the lab, its services (water, electricity, HVAC etc.), the ability to diagnose problems, organisation of repairs/maintenance and liaising with contractors. I also designed and introduced new electronic procedures and on-line systems to improve efficiency and collaboration, and ran our research group's website.
Gala Theatre | Millennium Place, Durham DH1 1WA
Woolworths Epsom | 46 High Street, Epsom, Surrey, KT19 8AL
Other Interests: Badminton, squash, singing, sailing, skiing, computer programming and website building
Referees are available on request.